Chimerin 2 - Wikipedia日本語版アーカイブ | wikipedia-is-dead.com

CHN2
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1XA6
識別子
記号	CHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3, chimerin 2
外部ID	OMIM: 602857 MGI: 1917243 HomoloGene: 31213 GeneCards: CHN2
遺伝子の位置 (マウス)
染色体	6番染色体 (マウス)
終点	54,278,795 bp
RNA発現パターン
	; ; ; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 血漿タンパク結合; • 金属イオン結合; • GTPase activator activity;
細胞の構成要素	• 細胞質; • 細胞質基質; • 膜;
生物学的プロセス	• intracellular signal transduction; • regulation of small GTPase mediated signal transduction; • シグナル伝達; • positive regulation of signal transduction; • positive regulation of GTPase activity; • regulation of GTPase activity;
	出典:Amigo / QuickGO
オルソログ
	1124
	69993
	ENSG00000106069
	ENSMUSG00000004633
	P52757,B3VCG5,H0YG02
	Q80XD1
NM_001039936; NM_001293069; NM_001293070; NM_001293071; NM_001293072;
	NM_001293073; NM_001293075; NM_001293076; NM_001293077; NM_001293078; NM_001293079; NM_001293080; NM_001293081; NM_004067; NM_001398427
	NM_001163640; NM_023543; NM_001311133; NM_001311134
NP_001035025; NP_001279998; NP_001279999; NP_001280000; NP_001280001;
	NP_001280002; NP_001280004; NP_001280005; NP_001280006; NP_001280007; NP_001280008; NP_001280009; NP_001280010; NP_004058
	NP_001157112; NP_001298062; NP_001298063; NP_076032
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

β-chimaerin（ベータ-キメリン、ベータ-カイメリン）はヒトにおいてCHN2遺伝子にコードされているタンパク質である^[4]^[5]。

この遺伝子はchimerinファミリーのメンバーであり、ホルボールエステル/DAGタイプ亜鉛フィンガー、Rho-GAPドメイン、SH2ドメインを持つタンパク質をコードしている。このタンパク質は、リン脂質結合およびジアシルグリセロール (DAG) の結合が誘導するタンパク質の細胞質ゾルからゴルジ体膜への移行によって制御されているGTPアーゼ活性化タンパク質活性を有する。このタンパク質は平滑筋細胞の増殖および移動に役割を果たしている。この遺伝子の発現の減少は悪性度の高い神経膠腫および乳がんと関連しており、この遺伝子の発現の上昇はリンパ腫と関連している。この遺伝子の変異は、ヒトの統合失調症と関連している。異なるアイソフォームをコードしている選択的転写スプライシングバリアントが同定されている^[5]。

脚注

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004633 - Ensembl, May 2017
↑ Human PubMed Reference:
↑ Mouse PubMed Reference:
↑ Leung T, How BE, Manser E, Lim L (Jun 1994), “Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain”, J Biol Chem 269 (17): 12888–92, PMID 8175705
1 2 “Entrez Gene: CHN2 chimerin (chimaerin) 2”. 2012年1月26日閲覧。

推薦文献

Yuan S, Miller DW, Barnett GH, et al. (1995), “Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma”, Cancer Res. 55 (15): 3456–61, PMID 7614486
Caloca MJ, Fernandez N, Lewin NE, et al. (1997), “Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters”, J. Biol. Chem. 272 (42): 26488–96, doi:10.1074/jbc.272.42.26488, PMID 9334226
Caloca MJ, Garcia-Bermejo ML, Blumberg PM, et al. (1999), “beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain”, Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11854–9, doi:10.1073/pnas.96.21.11854, PMC 18376, PMID 10518540
Caloca MJ, Wang H, Delemos A, et al. (2001), “Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor”, J. Biol. Chem. 276 (21): 18303–12, doi:10.1074/jbc.M011368200, PMID 11278894
Wang H, Kazanietz MG (2002), “Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain”, J. Biol. Chem. 277 (6): 4541–50, doi:10.1074/jbc.M107150200, PMID 11689559
Strausberg RL, Feingold EA, Grouse LH, et al. (2003), “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”, Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903, doi:10.1073/pnas.242603899, PMC 139241, PMID 12477932
Scherer SW, Cheung J, MacDonald JR, et al. (2003), “Human chromosome 7: DNA sequence and biology”, Science 300 (5620): 767–72, doi:10.1126/science.1083423, PMC 2882961, PMID 12690205
Nishiu M, Yanagawa R, Nakatsuka S, et al. (2003), “Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression”, Jpn. J. Cancer Res. 93 (8): 894–901, PMID 12716467
Hillier LW, Fulton RS, Fulton LA, et al. (2003), “The DNA sequence of human chromosome 7”, Nature 424 (6945): 157–64, doi:10.1038/nature01782, PMID 12853948
Caloca MJ, Wang H, Kazanietz MG (2004), “Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor”, Biochem. J. 375 (Pt 2): 313–21, doi:10.1042/BJ20030727, PMC 1223697, PMID 12877655
Ota T, Suzuki Y, Nishikawa T, et al. (2004), “Complete sequencing and characterization of 21,243 full-length human cDNAs”, Nat. Genet. 36 (1): 40–5, doi:10.1038/ng1285, PMID 14702039
Gerhard DS, Wagner L, Feingold EA, et al. (2004), “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”, Genome Res. 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC 528928, PMID 15489334
Canagarajah B, Leskow FC, Ho JY, et al. (2004), “Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin”, Cell 119 (3): 407–18, doi:10.1016/j.cell.2004.10.012, PMID 15507211
Hashimoto R, Yoshida M, Kunugi H, et al. (2005), “A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men”, Schizophrenia Research 73 (2–3): 383–5, doi:10.1016/j.schres.2004.01.017, PMID 15653288
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005), “High-throughput mapping of a dynamic signaling network in mammalian cells”, Science 307 (5715): 1621–5, doi:10.1126/science.1105776, PMID 15761153
Yang C, Liu Y, Leskow FC, et al. (2005), “Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.”, J. Biol. Chem. 280 (26): 24363–70, doi:10.1074/jbc.M411629200, PMID 15863513
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006), “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”, Genome Res. 16 (1): 55–65, doi:10.1101/gr.4039406, PMC 1356129, PMID 16344560
Siliceo M, García-Bernal D, Carrasco S, et al. (2006), “Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells”, J. Cell. Sci. 119 (Pt 1): 141–52, doi:10.1242/jcs.02722, PMID 16352660
Yang C, Liu Y, Lemmon MA, Kazanietz MG (2006), “Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4”, Mol. Cell. Biol. 26 (3): 831–42, doi:10.1128/MCB.26.3.831-842.2006, PMC 1347034, PMID 16428439

⌬ Phoenix Mesh CID: 未登録 IPFS未登録 📡 0ピア N=1 CRITICAL PQS B68

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004633 - Ensembl, May 2017

[2] Human PubMed Reference:

[3] Mouse PubMed Reference:

[pmid8175705-4] Leung T, How BE, Manser E, Lim L (Jun 1994), “Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain”, J Biol Chem 269 (17): 12888–92, PMID 8175705

[entrez-5] 1 2 “Entrez Gene: CHN2 chimerin (chimaerin) 2”. 2012年1月26日閲覧。

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脚注

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