ペリオスチン
ペリオスチン (periostin) は、ヒトのPOSTN遺伝子にコードされたタンパク質である[5][6]。ペリオスチンはαVβ3およびαVβ5インテグリンのリガンドとして機能し、上皮細胞の接着および遊走を支える[7]。
臨床的重要性
喘息
ペリオスチンは喘息と関連している。これは、喘息の試験薬であるレブリキズマブ (lebrikizumab) に利用されている[8]。
癌
ペリオスチンの過剰発現は様々な種類の癌で報告されており、腫瘍細胞の環境で最も頻繁に見られる[7][9]。最近研究では、ペリオスチンは正常組織や原発腫瘍間質中の線維芽細胞によって発現される細胞外マトリックスの構成要素であることが明らかにされている。転移性コロニー形成は 浸潤性がん細胞によるストロマ中のペリオスチンの誘導が必要である。ペリオスチンの産生はTGF-β2あるいはTGF-β3によって肺線維芽細胞において上方制御される。TGF-β3は浸潤性がん幹細胞によって分泌される（MMTV-PyMTマウス乳癌モデル）[10]。
| 細胞株 | 起源 | POSTN/ACTB1 |
|---|---|---|
| U2OS | 骨肉腫 | 3.5±1.7 |
| LB96 | ユーイング肉腫 | 0 |
| LB23-1 | 横紋筋肉腫 | 0.1±0.1 |
| HeLa | 子宮頸癌 | 3.0±0.4 |
| PA-1 | 卵巣奇形腫 | 1.4±0.1 |
| LB37-1 | NSCLC | 2.8±0.6 |
| LB85 | SCLC | 3.4±0.2 |
| LB92 | SCLC | 0.6±0.2 |
| LB1047 | 腎細胞癌 | 0.8±0.2 |
| BB64 | 腎細胞癌 | 0.08±0.01 |
| LB108 | 結腸直腸癌 | 0 |
| MCF7 | 乳癌 | 0 |
| Hs578T | 乳癌 | 3693±86 |
| Panc-1 | 膵癌 | 0 |
| Capan-1 | 膵癌 | 0 |
| Huh-7 | 肝細胞癌 | 0.3±0.07 |
| LB831 | 膀胱癌 | 1748±74 |
| MZGC3 | 胃癌 | 0 |
| A172 | 膠芽腫 | 45±4 |
| MZ2 | メラノーマ | 2.3±0.7 |
| LB39 | メラノーマ | 0.5±0.03 |
| LB2586-7 | メラノーマ | 3.4±0.3 |
| LB2201-3 | メラノーマ | 4.2±0.4 |
| A375 | メラノーマ | 4.7±1.2 |
1 (cDNA POSTN/cDNA ACTB) × 104
脚注
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000133110 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027750 - Ensembl, May 2017
- ↑ Human PubMed Reference:
- ↑ Mouse PubMed Reference:
- ↑ Takeshita S, Kikuno R, Tezuka K, Amann E (Sep 1993). “Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I”. Biochem J. 294 ( Pt 1): 271–8. PMC 1134594. PMID 8363580.
- ↑ “Entrez Gene: POSTN periostin, osteoblast specific factor”. 2012年6月12日閲覧。
- 1 2 Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). “Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility”. Cancer Res. 62 (18): 5358–64. PMID 12235007.
- ↑ Kraft M (2011). “Asthma phenotypes and interleukin-13--moving closer to personalized medicine”. N. Engl. J. Med. 365 (12): 1141-1144. PMID 21879891.
- ↑ Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2011). “Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.”. Int. J. Cancer 128 (2): 352–60. doi:10.1002/ijc.25591. PMID 20715172.
- ↑ Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J (2011). “Interactions between cancer stem cells and their niche govern metastatic colonization”. Nature 481 (7379): 85-89. doi:10.1038/nature10694. PMID 22158103.
- ↑ Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. (2007). “Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.”. Molecular Cancer 6 (80). doi:10.1186/1476-4598-6-80. PMID 18086302.
推薦文献
- Sasaki H, Dai M, Auclair D, et al. (2001). “Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas.”. Cancer 92 (4): 843–8. doi:10.1002/1097-0142(20010815)92:4<843::AID-CNCR1391>3.0.CO;2-P. PMID 11550156.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dunham A, Matthews LH, Burton J, et al. (2004). “The DNA sequence and analysis of human chromosome 13.”. Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Shao R, Bao S, Bai X, et al. (2004). “Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.”. Mol. Cell. Biol. 24 (9): 3992–4003. doi:10.1128/MCB.24.9.3992-4003.2004. PMC 387763. PMID 15082792.
- Bao S, Ouyang G, Bai X, et al. (2004). “Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.”. Cancer Cell 5 (4): 329–39. doi:10.1016/S1535-6108(04)00081-9. PMID 15093540.
- Kim CJ, Yoshioka N, Tambe Y, et al. (2005). “Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells.”. Int. J. Cancer 117 (1): 51–8. doi:10.1002/ijc.21120. PMID 15880581.
- Chang Y, Lee TC, Li JC, et al. (2005). “Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma.”. Head Neck 27 (10): 873–82. doi:10.1002/hed.20253. PMID 16136586.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”. J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Yan W, Shao R (2006). “Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.”. J. Biol. Chem. 281 (28): 19700–8. doi:10.1074/jbc.M601856200. PMID 16702213.
- Försti A, Jin Q, Altieri A, et al. (2007). “Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis.”. Breast Cancer Res. Treat. 101 (1): 83–93. doi:10.1007/s10549-006-9265-1. PMID 16807673.
- Grigoriadis A, Mackay A, Reis-Filho JS, et al. (2007). “Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.”. Breast Cancer Res. 8 (5): R56. doi:10.1186/bcr1604. PMC 1779497. PMID 17014703.
- Baril P, Gangeswaran R, Mahon PC, et al. (2007). “Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.”. Oncogene 26 (14): 2082–94. doi:10.1038/sj.onc.1210009. PMID 17043657.
- Siriwardena BS, Kudo Y, Ogawa I, et al. (2007). “Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer.”. Br. J. Cancer 95 (10): 1396–403. doi:10.1038/sj.bjc.6603431. PMC 2360586. PMID 17060937.
- Li JS, Sun GW, Wei XY, Tang WH (2007). “Expression of periostin and its clinicopathological relevance in gastric cancer.”. World J. Gastroenterol. 13 (39): 5261–6. PMID 17876898.
- Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2010). “Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.”. Calcif. Tissue Int. 87 (4): 341–50. doi:10.1007/s00223-010-9391-y. PMID 20567965.
- Kashyap MK,” et al. (2010). “Overexpression of Periostin and Lumican in Esophageal Squamous Cell Carcinoma.”. Cancers. 2 (1): 133–142. doi:10.3390/cancers2010133.
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