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EZH1
識別子
記号	EZH1, KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit
外部ID	OMIM: 601674 MGI: 1097695 HomoloGene: 20458 GeneCards: EZH1
遺伝子の位置 (ヒト)
染色体	17番染色体 (ヒト)
終点	42,745,049 bp
遺伝子の位置 (マウス)
染色体	11番染色体 (マウス)
終点	101,117,289 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• メチルトランスフェラーゼ活性; • トランスフェラーゼ活性; • クロマチン結合; • histone-lysine N-methyltransferase activity; • DNA-binding transcription factor activity, RNA polymerase II-specific; • DNA結合; • transcription corepressor activity;
細胞の構成要素	• ESC/E(Z) complex; • 細胞核; • 核質; • テロメア;
生物学的プロセス	• histone H3-K27 methylation; • 解剖学的構造の形態形成; • メチル化; • regulation of transcription, DNA-templated; • 海馬発生; • transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • chromatin organization; • negative regulation of transcription by RNA polymerase II; • クロマチンリモデリング;
	出典:Amigo / QuickGO
オルソログ
	2145
	14055
	ENSG00000108799
	ENSMUSG00000006920
	Q92800,K7EM79
	P70351
	NM_001991; NM_001321079; NM_001321081; NM_001321082
	NM_007970
	NP_001308008; NP_001308010; NP_001308011; NP_001982
NP_031996; NP_001390736; NP_001390738; NP_001390739; NP_001390740;
	NP_001390741; NP_001390742; NP_001390743; NP_001390744; NP_001390745; NP_001390747; NP_001390750; NP_001390751
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

ヒストン-リジン-N-メチルトランスフェラーゼEZH1（enhancer of zeste homolog 1）は、ヒトではEZH1遺伝子にコードされるタンパク質である^[5]^[6]。

機能

マウスでは、EZH1とEZH2は共にヒストンH3K27のトリメチル化を司り、毛包の恒常性と創傷治癒に必要不可欠である^[7]。またEZH1は、幹細胞の同一性の維持と多能性の発揮に関するEZH2の機能を補完する^[8]。

出典

1 2 3 GRCh38: Ensembl release 89: ENSG00000108799 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006920 - Ensembl, May 2017
↑ Human PubMed Reference:
↑ Mouse PubMed Reference:
↑ “Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1”. Genomics 37 (2): 161–71. (Feb 1997). doi:10.1006/geno.1996.0537. PMID 8921387.
↑ “Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)”. 2021年9月5日閲覧。
↑ “EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.”. Genes Dev. 25 (5): 485–98. (Mar 2011). doi:10.1101/gad.2019811. PMC 3049289. PMID 21317239.
↑ “EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.”. Mol Cell 32 (4): 491–502. (Nov 2008). doi:10.1016/j.molcel.2008.10.016. PMC 2630502. PMID 19026780.

関連文献

“Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.”. Genomics 28 (3): 530–42. (1996). doi:10.1006/geno.1995.1185. PMID 7490091.
“Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17.”. Genomics 25 (1): 238–47. (1995). doi:10.1016/0888-7543(95)80131-5. PMID 7774924. https://zenodo.org/record/1258609.
“Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21.”. Genomics 25 (1): 248–55. (1995). doi:10.1016/0888-7543(95)80132-6. PMID 7774925.
“22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.”. Genomics 25 (1): 256–63. (1995). doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
“Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”. DNA Res. 4 (2): 141–50. (1997). doi:10.1093/dnares/4.2.141. PMID 9205841.
“Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.”. Biochim. Biophys. Acta 1395 (2): 151–8. (1998). doi:10.1016/s0167-4781(97)00156-5. PMID 9473645.
“The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.”. Mol. Cell. Biol. 18 (5): 2825–34. (1998). doi:10.1128/mcb.18.5.2825. PMC 110661. PMID 9566901.
“Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.”. Mol. Cell. Biol. 18 (6): 3572–9. (1998). doi:10.1128/MCB.18.6.3572. PMC 108938. PMID 9584197.
“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
“The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

この項目は、生物学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:生命科学／Portal:生物学）。

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000108799 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006920 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid8921387-5] “Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1”. Genomics 37 (2): 161–71. (Feb 1997). doi:10.1006/geno.1996.0537. PMID 8921387.

[entrez-6] “Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)”. 2021年9月5日閲覧。

[pmid21317239-7] “EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.”. Genes Dev. 25 (5): 485–98. (Mar 2011). doi:10.1101/gad.2019811. PMC 3049289. PMID 21317239.

[pmid19026780-8] “EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.”. Mol Cell 32 (4): 491–502. (Nov 2008). doi:10.1016/j.molcel.2008.10.016. PMC 2630502. PMID 19026780.

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機能

出典

関連文献

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